There’s no one-size-fits-all answer to this question, as the best way to clean spider poop will vary depending on the type of spider and its feces. However, some tips on how to clean spider poop include using a plunger or vacuum cleaner to suck out the feces, using a baking soda and water mixture to clean up any messes made with soap and water, or using a plunger and bucket to scoop out the feces.