There are a few ways to delete items from Depop.com. You can use the “Delete Item” button on the top left of the screen, or you can use the “Customize My Profile” link on the bottom right of the screen. If you use the “Delete Item” button, Depop will ask you to confirm your deletion before deleting the item. If you use the “Customize My Profile” link, Depop will ask you to choose a reason for deleting the item. You can choose to delete an item because it is no longer needed, because it is outdated, or because it is no longer working properly.